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1 edition of Papilloma of the bladder in the chemical industry found in the catalog.

Papilloma of the bladder in the chemical industry

Papilloma of the bladder in the chemical industry

a study of its cause and prevention.

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Published by Association of British Chemical Manufacturers in London .
Written in English


Edition Notes

ContributionsAssociation of British Chemical Manufacturers.
ID Numbers
Open LibraryOL19743131M

  Characteristics of the study population of former and active chemical workers. Table 1 describes the study population of 1, tumor-free men and 20 cases who developed 21 bladder tumors between and (13 high-grade bladder cancers, 5 low-grade bladder cancers, and 3 papillomas). In this prospective study, one case was initially diagnosed with a papilloma, and   AbstractV. SUMMARYCarcinogenicity tests showed that addition of the antioxidant BHA to the diet of F rats induced high incidences of papilloma and squamous cell carcinoma of the forestomach of both sexes. Male hamsters given BHA for 24 weeks also developed papilloma showing downward growth into the submucosa of the forestomach. These results indicate that BHA should be

An investigation was performed to evaluate the feasibility of a study of bladder cancer incidence or mortality at a small chemical facility in southern Michigan where workers were subject to exposure to 4,4'-methylenebis(2-chloroaniline) () (MBOCA). In order to investigate the relationship between tobacco smoking, occupations, and altered patterns of p53 expression, we have analyzed a group of incident patients with superficial

The remaining chemicals could not be classified. The most extensive monograph evaluates occupational exposures in the textile manufacturing industry. Evaluations of risk concentrate on epidemiological evidence of carcinogenicity at the oral and pharyngeal, oesophagus and stomach, nasal cavity, larynx, lung, and bladder :// survivin did not detect cases with papilloma or low-grade bladder. cancer in UroScreen, whereas the sensitivity was better for high- and Chemical Industry (BG RCI), Heidelberg, Germany,


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Papilloma of the bladder in the chemical industry Download PDF EPUB FB2

In the Dyestuffs Group of the Association of British Chemical Manufacturers organized and financed a Papilloma of the bladder in the chemical industry book research project on industrial papilloma of the bladder with special reference to the dyestuffs industry.

At the outset the scheme was to be focused on 3 suspected compounds-alpha-naphthylamine, beta-naphthylamine and benzidine. An industrial field survey into the problem of the The Report of the investigation into the incidence of tumours of the urinary bladder sponsored by the Association of British Chemical Manufacturers was reviewed recently [this Bulletin,v.

29, ]. The present paper is the result of a 5-year field survey of the problem, conducted in the factories of, and among the workpeople employed by, a group of member firms of the :// fact that cancer of the bladder occurs as an oc- cupational disease in certain branches of the chemical industry, particularly in workers in the aniline industry.

This has been proved by experiments on animals, in which a number ol compounds of the group OC azo dyes and certain primary aromatic amines3 caused can- cer 01 the ://() The utility of intravesical chemotherapy in case of failure of BCG immunotherapy may lead to favorable results in some patients.

From this perspective, chemotherapy with mitomycin C led to a favorable response in only 18% of cases (Malmström et al., ).Moreover, gemcitabine, apaziquone, valrubicin, as well as thermochemotherapy (Synergo) have also been tried, in small series of :// The Lancet ORIGINAL ARTICLES BLADDER TUMOURS IN THE ELECTRIC-CABLE INDUSTRY JoanM.

Davies M.A. Oxon., Dip. P.S.A. a b a From the Department of Clinical Research, Royal Marsden Hospital, United Kingdom b and Institute of Cancer Research, London, S.W.3, United Kingdon IN Case and Hosker investigated the incidence of tumours of the bladder in the rubber industry in The results of an investigation of the incidence of bladder tumours in workers in the rubber industry, undertaken in and published in [CASE and HOSKER, this Bulletin,v.

29, ], supported the hypothesis that a risk of development of these tumours was introduced when a certain rubber anti-oxidant came into use in Tumours had already occurred in chemical workers INTRODUCTION. Bladder Cancer represents the 6th most common cancer diagnosis inaccounting for % of all new cancer cases [].Around 70% of new diagnoses represent Non-Muscle Invasive Bladder Cancer (NMIBC), of which 10% are CIS [].The untreated natural history of CIS is progression to Muscle Invasive Bladder Cancer (MIBC) in 50% of cases at 5 years [].

A review is presented of 66 cases of bladder tumours occurring among workers in a factory where aniline dyes are prepared; 23 affected men were exposed only to benzidine; 15 had worked solely on beta naphthylamine. Others had been exposed to several substances. The processes followed in the manufacture of benzidine and beta naphthylamine are outlined; the latter dye is no longer After a short discussion of occupational cancer in general, the authors give a table classifying industrial.

cancers by their causes, indicating in which cases experimental proof has been obtained, and then proceed to discuss recent work on the groups in which they are specially interested. Occuupational Cancer in the Dyestuffs IndustryWorkers in the manufacture and use of certain dye Urothelial papilloma and diffuse papillomatosis.

Urothelial papilloma is a benign exophytic urothelial neoplasm that typically occurs in patients younger than 50 years of age. 6 The male-to-female ratio is 2: 1.

The most common symptom is hematuria. 6 Most tumors are located near the ureteric orifices. Urothelial papilloma may recur, but recurrent papilloma does not progress. 6,7   Genetic Factors. The genetic factors associated with bladder cancer development can be categorized into familial history, genetic polymorphism, phenotypes of acetyltransferase, activation and mutation of oncogenes and tumor suppressor genes (TSG), and chromosomal changes.

Oncogenes associated with bladder cancer include those of the RAS gene family, including the p21 RAS The whole-life occupational histories of 1, patients ( men and women) with papilloma and carcinoma of the bladder were analyzed.

Bladder tumor patients whose smoking habits were known were matched with surgical control patients ( men and 50 women) and with other cancer patients ( men and 39 women) for sex, age decade, habitat   Bladder cancer in rubber workers. Do screening and doctors' awareness distort the statistics. Fox AJ, White GC.

The use of recognised carcinogens in the rubber industry before led to the introduction of screening progammes offering urinary cytology to workers who had been :// COVID Resources.

Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus Abstract.

As early as — long before any clues to the etiology of tumors in other organs were apparent — Rehn reported his observations of the increased occurrence of tumors of the urinary bladder in laborers who had daily contact with basic fuchsin over a long period.

He suspected a causal connection between aniline, nitrobenzol, toluidine, and basic fuchsin and the development of the The frequency of bladder cancer in workers exposed to dyes is relatively high, although the exact number of cases in each industry in which exposure to such dyes occurs is difficult to determine.

The total number of occupa- tional bladder cancers reported since Rehn's 39 initial observations is estimated by Lock- wood M to be 2,()   Epidemiology. Worldwide in, new cases of bladder cancer were diagnosed anddeaths occurred. 1 The majority of bladder cancers occur in males; bladder cancer is the sixth most common cancer in men and the seventeenth most common cancer in women.

The highest incidence rates are found in Europe, Northern Africa, the Middle East and Northern America, and the Abstract. Bladder cancer accounts for % of the new cases of cancer diagnosed each year in the United States.

It was estimated in t new cases of bladder cancer would be seen, w cases appearing in males in females [4]. Exact data concerning the relation of ^-glucuronidase activity to the malignancy of the related neoplasms are lacking. Only Sorrentino and Romano were able to find normal /^-glucuronidase values in patients with bladder papillomas On the contrary, our results revealed an activity increase even in bladder papilloma :// Case RAM, Hosker ME, Mc Donald DM et al.

() Tumours of the urinary bladder in workmen engaged in manufacture and use of certain dye-stuff intermediates in British chemical industry. Part I. The role of aniline, benzidine, alpha-naphthylamine, and betanaphthylamine.

Br. Case, R.A.M. and Pearson, J.T. () Tumours of the urinary bladder in workman engaged in the manufactureand use of certain dyestuff intermediates in the British chemical industry.

Part II. Further consideration of therole of aniline and of the manufacture of auramine and magenta (fuchsin) as possible causative agents. Br. Med.

Excluding low level exposures, the number of workers (blue-collars) likely exposed to bladder cancer risk in the industry and services is ± 11 ( ± 7 men, and   bladder cancer in a patient with gross hematuria is 20 perc15 and with microscopic hematuria is 2 per­ cent. 16­18 Symptoms of bladder irritation, such as uri­