3 edition of Connective tissue of the normal and fibrotic human liver found in the catalog.
Connective tissue of the normal and fibrotic human liver
Includes bibliographical references and indexes.
|Statement||edited by U. Gerlach ... [et al.] ; with a synoptic review by H. Popper.|
|Contributions||Gerlach, U. 1925-, Popper, Hans, 1903-|
|LC Classifications||RC847 C67 1982|
|The Physical Object|
|Pagination||xi, 268 p. :|
|Number of Pages||268|
|ISBN 10||3136284011, 0865770563|
Connective tissue growth factor is strongly upregulated in fibrotic liver tissue and plays a pivotal role in fibrogenesis of liver (Gressner and Gressner, ; Weiskirchen, ). It is. The Metabolic Organization of the Adult Human Liver: A Comparative Study of Normal, Fibrotic, and Cirrhotic Liver Tissue LORRAINE RACINE-SAMSON,1 JEAN-YVES SCOAZEC,1 ANTONIA D’ERRICO,2 MICHELANGELO FIORENTINO,2 LAURENCE CHRISTA,3 ALAIN MOREAU,1 CORRADO RODA,1 WALTER F. GRIGIONI,2 AND GE´RARD FELDMANN1 Little is known Cited by:
The capsule can be distinguished from most pathologic fibrous tissue by its density and maturity, and it often contains blood vessels and bile ducts. Similar artifacts can be found in biopsy samples when the needle enters the liver at an angle close to the capsule or in a wedge biopsy that contains capsular fibrosis tissue on two surfaces. Specific antibodies to collagen type IV, laminin, and fibronectin were used to localise these proteins by indirect immunofluorescence in frozen sections of normal and fibrotic liver. In normal livers distinct staining was found in basement membranes of blood and lymph vessels, of bile ducts and ductules and around nerve by:
Fibrosis can occur as systemic disease or restricted to single organs; it is characterized by pathologic new-formation of connective tissue. Most fibrotic Cited by: 2. human immunodeficiency virus. thick connective tissue layer containing blood vessels, lymphatic vessels, and nerves. Define Muscularis: irreversible disease, replacing normal liver cells with hard, fibrous scar tissue. Vaccines are available to prevent Hepatitis? A and B. Symptoms of Hepatitis include.
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Click on the article title to read : Mark Zern. Connective tissue of the normal and fibrotic human liver Edited by U. Gerlach, G. Pott, J. Rauterberg, and B. Voss. pp., illustrations, 43 tables, $Author: John T. Galambos. Klinische Wochenschrift. Klinische Wochenschrift.
JanuaryVol Issue 1, pp 1–7 | Cite as. Connective tissue components of the normal and fibrotic human liver. Connective tissue components of the normal and fibrotic human liver.
Clinical aspects. Pott G, Rauterberg J, Voss B, Gerlach U. In this second part, clinical aspects of connective tissue metabolism in the liver will be described and two main aspects considered.
The first is the possibility to monitor the activity of fibrosis by the use of metabolites and enzymes of connective tissue by: 7.
Connective tissue components of the normal and fibrotic human liver. Summary. In this second part, clinical aspects of connective tissue metabolism in the liver will be described and two main aspects considered. The first is the possibility to monitor the activity of fibrosis by the use of metabolites and enzymes of connective tissue by: The normal liver contains typical connective tissue proteins (collagens, structural glycoproteins and proteoglycans) not only in vessel walls, perivascular areas and in the capsule, but they occur also in small amounts in the parenchyma, mainly in the space of Disse along the sinusoidal by: Connective tissue conﬁ guration in the human liver hilar region with special reference to the liver capsule and vascular sheath S HOGO H AYASHI 1.
Liver fibrosis is most often characterized by accumulation of wound healing myofibroblasts that replace normal hepatic tissue with scar at the site of injury [1,2]. Autoimmune hepatitis is an immune mediated inflammation of the liver of unknown cause. The disease leads to progressive inflammatory and fibrotic process in the liver [ 4, 5 ].
The condition is chronic and characterized by interface hepatitis, hypergammaglobulinaemia and liver-specific serum by: 4. Liver fibrosis is the excessive accumulation of scar tissue which results from ongoing inflamed liver and liver cell death that may occur in most of the types of chronic liver disease.
The abnormal spherical areas of the cells from as dying cells are normally replaced by the regenerating cells.
COVID campus closures: see options for getting or retaining Remote Access to subscribed content. ts with connective tissue diseases has been well documented but is generally considered rare. Although advanced liver disease with cirrhosis and liver failure is rare in patients with connective tissue diseases, clinical and biochemical evidence of associated liver abnormalities is common.
Previous treatment with potentially hepatotoxic drugs or coincident viral hepatitis has usually. Connective tissue growth factor in human liver cirrhosis. Connective tissue growth factor (CTGF) belongs to a family of factors that regulate fibrogenesis and wound healing.
While the significance of transforming growth factor beta (TGF-beta) in liver fibrosis is well established, the role of CTGF in fibrosing hepatopathy is still unknown.
In this second part, clinical aspects of connective tissue metabolism in the liver will be described and two main aspects considered. The first is the possibility to monitor the activity of fibrosis by the use of metabolites and enzymes of connective tissue by: 7.
Bearing this limitation in mind, the following observations can be proposed: (i) normal liver tissue contains up to about 4% connective tissue but (ii) its stiffness does not seem to be significantly dependent on connective tissue content; (iii) connective tissue content of carcinoma/fibrosis samples varies considerably, from 2% to 85%; (iv) the corresponding stiffness values are in Cited by: Results Normal Liver Tissue The distribution of the various different VLA chains in normal human liver tissue is shown in Table 3.
VLA-a1 was expressed in portal tracts on vascular endothelium and in the connective tissue stroma but not on bile duct by: Connective tissue of the normal and fibrotic human liver: present state of biochemistry, clinical evaluation, and treatment: international symposium at the Medizinische Universitätsklinik Münster/West Germany, Cirrhosis, irreversible change in the normal liver tissue that results in the degeneration of functioning liver cells and their replacement with fibrous connective tissue.
Cirrhosis can have a number of causes; the term is applied whenever the end result is scarring of the liver. In the normal human liver, fibrillin-1 and elastin are found in the portal tracts (vessel walls and connective tissue) as well as in the wall of centrilobular by: Results: Ribonuclease protection assays demonstrated connective tissue growth factor mRNA was increased 3–5-fold in human fibrotic liver compared with normal.
RT-PCR showed this mRNA was increased in carbon-tetrachloride-treated rat by:. Fibrosis develops when the liver is repeatedly or continuously damaged.
After a single episode of injury, even if severe (as with acute hepatitis), the liver commonly repairs itself by making new liver cells and attaching them to the web of connective tissue (internal structure) that is left when liver cells r, if injury is repeated or continuous (as occurs in chronic hepatitis.Fibrotic changes can occur in various vascular disorders, including cardiac disease, cerebral disease and peripheral vascular disease, as well as in all the main tissues and organ systems, including the skin, kidney, lung and liver.
Fibrosis is a troubling problem for an increasing number of individuals and is a common pathological sequela of many persistent inflammatory Cited by: In this work, the CRBP-1 expression was studied by immunohistochemistry in the different liver cell populations, including HSCs and portal fibroblasts, of normal liver and of fibrotic and.